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J Autism Dev Disord. 2017 Jul;47(7):2067-2079. doi: 10.1007/s10803-017-3130-4.

Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children.

Author information

1
Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA. Stacey.Alexeeff@kp.org.
2
Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA.
3
McKesson Corporation, San Francisco, CA, USA.
4
The Permanente Medical Group, Pediatrics, Oakland, CA, USA.
5
Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.
6
Center for Biomedical Informatics, University of Tennessee Health Sciences Center, Memphis, TN, USA.

Abstract

This study examines medical conditions diagnosed prior to the diagnosis of autism spectrum disorder (ASD). Using a matched case control design with 3911 ASD cases and 38,609 controls, we found that 38 out of 79 medical conditions were associated with increased ASD risk. Developmental delay, mental health, and neurology conditions had the strongest associations (ORs 2.0-23.3). Moderately strong associations were observed for nutrition, genetic, ear nose and throat, and sleep conditions (ORs 2.1-3.2). Using machine learning methods, we clustered children based on their medical conditions prior to ASD diagnosis and demonstrated ASD risk stratification. Our findings provide new evidence indicating that children with ASD have a disproportionate burden of certain medical conditions preceding ASD diagnosis.

KEYWORDS:

Autism spectrum disorder; Comorbidity; Medical conditions

PMID:
28434058
PMCID:
PMC5487747
DOI:
10.1007/s10803-017-3130-4
[Indexed for MEDLINE]
Free PMC Article

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