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Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S507-S521. doi: 10.1016/j.dsx.2017.03.045. Epub 2017 Apr 5.

Evidence-based recommendations for insulin intensification strategies after basal insulin in type 2 diabetes.

Author information

1
Department of Endocrinology and Metabolism, Institute of Post-Graduate Medical Education and Research, Kolkata, India. Electronic address: drsujoyghosh2000@gmail.com.
2
Chellaram Diabetes Institute, Pune, India.
3
DiaCare, Ahmedabad, Gujarat, India.
4
Jothydev's Diabetes & Research Center, Trivandrum, India.
5
Diacon Hospital, Bangalore, India.
6
Department of Medicine, Motilal Nehru Medical College, Allahabad, India.
7
Department of Endocrinology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India.
8
Department of Endocrinology and Metabolism, Shri Rama Chandra University, Chennai, India.
9
King George's Medical University, Lucknow, India.
10
Jaipur Diabetes Research Center, Jaipur, India.
11
Diabetes & Obesity Center, New Delhi, India.
12
Gauhati Medical College, Guwahati, India.
13
Orange Diabetes Foundation, Pune, India.
14
Consultant Endocrinologist, Coimbatore, India.
15
Mahi Diabetes & Thyroid Care and Research Center, Jabalpur, India.
16
Ideas Diabetes Center, Rajkot, India.
17
Department of Medicine, Babu Banarasi Das University, Lucknow, India.
18
Diabetes Clinic and Research Center, Nagpur, India.
19
Sumeru Center, Ahmedabad, India.
20
Galaxy Specialty Center, Jaipur, India.
21
Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
22
India Diabetes Research Foundation, Chennai, India.
23
Advanced Center for Diabetes and Endocrine Care, Srinagar, India.
24
Lilavati and Bhatia Hospital and Grant Medical College, Mumbai, India.
25
Diabetes India, Mumbai, India.

Abstract

Over the time due to progressive nature of diabetes, proactive intensification of the existing insulin therapy becomes imminent as it minimizes patients' exposure to chronic hypo/hyperglycaemia and reduces weight gain while achieving individualized glycaemic targets. This review focuses on the strength of evidence behind various options for intensification, primarily the insulins as also the GLP-1 analogues. The recommendations presented here are meant to serve as a guide for the physician managing type 2 diabetes patients requiring insulin intensification upon failing of basal insulin therapy.

KEYWORDS:

Basal plus; GLP-1; Hypoglycaemia; Insulin intensification; Recommendations

PMID:
28433618
DOI:
10.1016/j.dsx.2017.03.045
[Indexed for MEDLINE]

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