Format

Send to

Choose Destination
Curr Cardiol Rep. 2017 Jun;19(6):52. doi: 10.1007/s11886-017-0858-6.

Targeting LDL Cholesterol: Beyond Absolute Goals Toward Personalized Risk.

Author information

1
Clalit Research Institute, Chief Physician's Office, Clalit Health Services, 101 Arlozorov Street, Tel Aviv, Israel. LeibowM@clalit.org.il.
2
Clalit Research Institute, Chief Physician's Office, Clalit Health Services, 101 Arlozorov Street, Tel Aviv, Israel.
3
Stanford University, Medical School Office Building X-322, 1265 Welch Road, Mail Code 5411, Stanford, CA, 94305, USA.

Abstract

PURPOSE OF REVIEW:

The aim of this study was to review and assess the evidence for low-density lipoprotein cholesterol (LDL-C) treatment goals as presented in current guidelines for primary and secondary prevention of cardiovascular disease.

RECENT FINDINGS:

Different sets of guidelines and clinical studies for secondary prevention have centered on lower absolute LDL-C targets [<70 mg/dL (<1.8 mmol/L)], greater percent reductions of LDL-C (≥50%), or more intense treatment to achieve greater reductions in cardiovascular risk. Population-based risk models serve as the basis for statin initiation in primary prevention. Reviews of current population risk models for primary prevention show moderate ability to discriminate [with c-statistics ranging from 0.67 to 0.77 (95% CIs from 0.62 to 0.83) for men and women] with poor calibration and overestimation of risk. Individual clinical trial data are not compelling to support specific LDL-C targets and percent reductions in secondary prevention. Increasing utilization of electronic health records and data analytics will enable the development of individualized treatment goals in both primary and secondary prevention.

KEYWORDS:

Cardiovascular disease prevention; Low-density lipoprotein cholesterol; Major adverse cardiac events; Statins

PMID:
28432662
PMCID:
PMC5815375
DOI:
10.1007/s11886-017-0858-6
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center