Format

Send to

Choose Destination
Curr Osteoporos Rep. 2017 Jun;15(3):121-125. doi: 10.1007/s11914-017-0356-1.

T Regulatory Cells in Bone Remodelling.

Author information

1
Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany. aline.bozec@uk-erlangen.de.
2
Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.

Abstract

PURPOSE OF THE REVIEW:

In this review, we present the role of regulatory T (Treg) cells in bone remodelling and bone-related disease such as osteoporosis or inflammatory bone loss. We also discuss the cellular and molecular mechanism how Treg cells regulate osteoclastogenesis.

RECENT FINDINGS:

Treg cells could regulate osteoclastogenesis by secreting TGF-β and IL-10 as well as IL-4 cytokines. Moreover, Treg cells can additionally regulate osteoclast differentiation, in a cell-to-cell contact via the cytotoxic T lymphocyte antigen (CTLA-4). The latter induces the apoptosis of osteoclasts dependent on CD80/86 in vitro and in vivo. Treg cells mediate immunosuppressive function that controls undesired immune reactions, such as autoimmunity. Recently, Treg cells have been shown to influence non-immunological processes, such as bone homeostasis. Accumulated evidences have demonstrated that Treg cells can suppress osteoclast differentiation in vitro and in vivo.

KEYWORDS:

Bone homeostasis; Osteoclast; Osteoporosis; Regulatory T cells

PMID:
28432597
DOI:
10.1007/s11914-017-0356-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center