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Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8). pii: a027730. doi: 10.1101/cshperspect.a027730.

Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals.

Author information

1
Department of Neurobiology, Northwestern University, Evanston, Ilinois 60208.
2
Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53719.
3
Department of Neuroscience, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania 19104-6058.

Abstract

Sleep is homeostatically regulated with sleep pressure accumulating with the increasing duration of prior wakefulness. Yet, a clear understanding of the molecular components of the homeostat, as well as the molecular and cellular processes they sense and control to regulate sleep intensity and duration, remain a mystery. Here, we will discuss the cellular and molecular basis of sleep homeostasis, first focusing on the best homeostatic sleep marker in vertebrates, slow wave activity; second, moving to the molecular genetic analysis of sleep homeostasis in the fruit fly Drosophila; and, finally, discussing more systemic aspects of sleep homeostasis.

PMID:
28432135
PMCID:
PMC5538413
DOI:
10.1101/cshperspect.a027730
[Indexed for MEDLINE]
Free PMC Article

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