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Brain Dev. 2017 Sep;39(8):687-692. doi: 10.1016/j.braindev.2017.03.027. Epub 2017 Apr 18.

Low glycemic index treatment in patients with drug-resistant epilepsy.

Author information

1
Division of Pediatric Neurology, Epilepsy Research Institute, Severance Children's Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.
2
Division of Dietetics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
3
Division of Pediatric Neurology, Epilepsy Research Institute, Severance Children's Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: hdkimmd@yuhs.ac.

Abstract

OBJECTIVE:

Low glycemic index treatment (LGIT) is a newly developed dietary therapeutic option for epilepsy that is less restrictive than the ketogenic diet (KD). Our objective was to determine the efficacy and tolerability of LGIT.

METHODS:

From March 2014 to February 2015, 36 patients received LGIT at Severance Children's Hospital. One-year seizure outcomes and side effects were evaluated.

RESULTS:

A total of 36 patients were assessed. Fourteen were female. Common diagnoses were Lennox-Gastaut syndrome (33%, 12/36) and Dravet syndrome (14%, 5/36). The median age at the initiation of the LGIT was 12.6years (min.=1.5, max.=28, interquartile range (IQR) 8-17). After 3months of therapy, 20 (56%) patients experienced a 50% or greater reduction in seizure frequency, which was maintained in 19 (53%) patients for 1year. Two (6%) patients became seizure-free after 3months of LGIT; they remained seizure-free for 1year. These two had Dravet syndrome and generalized epilepsy. Only three (8%) patients discontinued treatment within 1year. Adverse events were rare, and two patients (6%) reported transient diarrhea.

CONCLUSIONS:

LGIT effectively reduced seizure frequency in the present study, although seizure freedom was infrequently achieved. LGIT may be considered as a therapeutic option for patients with drug-resistant epilepsy, particularly those who find KD effective but intolerable.

KEYWORDS:

Children; Epilepsy; Ketogenic diet; Low glycemic index treatment

PMID:
28431772
DOI:
10.1016/j.braindev.2017.03.027
[Indexed for MEDLINE]

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