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Mol Cell. 2017 Apr 20;66(2):167-168. doi: 10.1016/j.molcel.2017.03.018.

Functional Enhancer Screening in Single Cells.

Author information

1
Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands. Electronic address: j.v.arensbergen@nki.nl.
2
Division of Gene Regulation, Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Department of Cell Biology, Erasmus University Medical Center, 3015GE Rotterdam, the Netherlands. Electronic address: b.v.steensel@nki.nl.

Abstract

In this issue of Molecular Cell, Xie et al. (2017) introduce Mosaic-seq, a powerful technology that combines CRISPRi and single-cell RNA-seq. This method enables the high-throughput assessment of contributions of enhancers to gene regulation.

KEYWORDS:

CRISPRi; barcoding; enhancer; functional screen; gene regulation; promoter; single-cell RNA sequencing

PMID:
28431229
DOI:
10.1016/j.molcel.2017.03.018
[Indexed for MEDLINE]
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