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Chem Senses. 2017 May 1;42(4):295-302. doi: 10.1093/chemse/bjw126.

Suppression of Oral Sweet Taste Sensation with Gymnema sylvestre Affects Postprandial Gastrointestinal Blood Flow and Gastric Emptying in Humans.

Author information

1
School of Health Sciences, Prefectural University of Hiroshima, 1-1-71 Ujina-higashi, Minami-ku, Hiroshima 734-8558, Japan.
2
Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, 1-1-71 Ujina-higashi, Minami-ku, Hiroshima 734-8558, Japan.
3
Department of Nutrition, Faculty of Health Care Sciences, Chiba Prefectural University of Health Sciences, 2-10-1 Wakaba, Mihama-ku, Chiba 261-0014, Japan.
4
Department of Health Promotion and Development, Graduate School of Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan and.
5
Institute for Liberal Arts, Department of Social and Human Sciences, Tokyo Institute of Technology, Ookayama 2-12-1-W9-1, Meguro-ku, Tokyo 152-8552, Japan.

Abstract

An oral sweet taste sensation (OSTS) exaggerates digestive activation transiently, but whether it has a role after swallowing a meal is not known. Gymnema sylvestre (GS) can inhibit the OSTS in humans. We explored the effect of the OSTS of glucose intake on gastrointestinal blood flow, gastric emptying, blood-glucose, and plasma-insulin responses during the postprandial phase. Eight participants ingested 200 g (50 g × 4 times) of 15% glucose solution containing 100 mg of 13C-sodium acetate after rinsing with 25 mL of 2.5% roasted green tea (control) or 2.5% GS solution. During each protocol, gastrointestinal blood flow and gastric emptying were measured by ultrasonography and 13C-sodium acetate breath test, respectively. Decreased subjective sweet taste intensity was observed in all participants in the GS group. The time to attain a peak value of blood flow in the celiac artery and gastric emptying were delayed in the GS group compared with the control group. At the initial phase after glucose intake, blood-glucose and plasma-insulin responses were lower in the GS group than those for the control group. These results suggest that the OSTS itself has a substantial role in controlling postprandial gastrointestinal activities, which may affect subsequent glycemic metabolism.

KEYWORDS:

cephalic phase; gastric emptying; gastrointestinal blood flow; glycemic control; oral sweet taste

PMID:
28431091
DOI:
10.1093/chemse/bjw126
[Indexed for MEDLINE]

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