Format

Send to

Choose Destination
Oncotarget. 2017 May 2;8(18):30539-30551. doi: 10.18632/oncotarget.15546.

Vascular endothelial growth factor A polymorphisms are associated with increased risk of coronary heart disease: a meta-analysis.

Author information

1
Cardiovascular Department, The Second Clinical Medical College of Fujian Medical University, Quanzhou, Fujian, China.
2
Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, China.
3
Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Fujian, China.
4
Department of Function, Agribusiness Hospital of Xishuangbanna, Jinghong, Yunnan, China.
5
Rheumatism Department, The Second Clinical Medical College of Fujian Medical University, Quanzhou, Fujian, China.
6
Department of Abdominal Surgery, Fujian Medical University Cancer Hospital, Fuzhou, Fujian, China.

Abstract

Coronary heart disease (CHD) is a common complex disease resulting from the interaction of multiple environmental and genetic factors. To assess the potential relationship of vascular endothelial growth factor (VEGFA) rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms with CHD risk, a comprehensive meta-analysis was conducted. A systematic search of EMBASE and PubMed online database for publications on VEGFA polymorphisms and risk of CHD was carried out. Crude Odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated to determine the association. A total of ten publications including 22 trails involving 2097 cases and 2867 controls were included in our pooled analysis. Overall, results of the present meta-analysis demonstrated a significant association between VEGFA rs699947 C>A polymorphism and an increased risk of CHD. After stratifying by ethnicity and CHD type, the association was also obtained. A significant association between VEGFA rs3025039 C>T polymorphism and risk of CHD was also found. For VEGFA rs2010963 G>C polymorphism, the polymorphism was associated with MI risk. In conclusion, our findings suggest that VEGFA rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms are risk factors for CHD. In the future, large sample size and well-designed epidemiologic studies are needed to confirm these conclusions.

KEYWORDS:

VEGFA; coronary heart disease; meta-analysis; polymorphism; susceptibility

PMID:
28430629
PMCID:
PMC5444763
DOI:
10.18632/oncotarget.15546
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Impact Journals, LLC Icon for PubMed Central
Loading ...
Support Center