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Oncotarget. 2017 Jul 11;8(28):46565-46579. doi: 10.18632/oncotarget.15425.

Lymphovascular invasion is a high risk factor for stage I/II colorectal cancer: a systematic review and meta-analysis.

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The Surgical Department of Coloproctology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Nanjing Medical University, Nanjing, China.
Department of Hepatobiliary Surgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an City, China.


The prognostic value of lymphovascular invasion (LVI) in stage I/II colorectal cancer (CRC) does not reach a consensus. To systematically assess prognostic significance of LVI, databases of PubMed, Web of Science, and Embase were searched from inception up to 10 Dec 2016. The pooled hazard ratio (HR) and 95% confidence intervals (CI) were used to determine the prognostic effects. Nineteen relevant studies including 9881 total patients were enrolled. Our results showed that LVI is significantly associated with poor prognosis in overall survival (OS) (HR=2.15, 95 % CI=1.72-2.68, P < 0.01) and disease-free survival (DFS) (HR=1.73, 95% CI=1.50-1.99, P < 0.01), which is similar in stage II patients. Further subgroup analysis revealed that the significance of the association between LVI and worse prognosis in CRC patients is not affected by below factors, including geographic setting, LVI positive rate, treatment, tumor site, and quality of the study. The current meta-analysis suggests that LVI may be a poor prognostic factor for stage I/II CRC patients.


colorectal cancer; lymphovascular invasion; meta-analysis; stage I/II; survival

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