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Sci Rep. 2017 Apr 21;7:46490. doi: 10.1038/srep46490.

Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese.

Zhang Y1,2,3,4, Li Y2,3,4, Wu M5, Cao P2,3,4, Liu X6, Ren Q2,3,4, Zhai Y2,3,4, Xie B2,3,4, Hu Y7, Hu Z8, Bei J9, Ping J2,3,4, Liu X2,3,4, Yu Y10, Guo B2,3,4, Lu H2,3,4, Liu G10, Zhang H2,3,4, Cui Y10, Mo Z7, Shen H8, Zeng YX9, He F1,2,3,4, Zhang H2,3,4, Zhou G2,3,4.

Author information

1
School of Life Sciences, Tsinghua University, Beijing, China.
2
State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.
3
National Engineering Research Center for Protein Drugs, Beijing, China.
4
National Center for Protein Sciences Beijing, Beijing, China.
5
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
6
Department of Laboratory Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
7
Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
8
Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.
9
State Key Laboratory of Oncology in Southern China, Guangzhou, China.
10
Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Abstract

The sodium taurocholate cotransporting polypeptide (NTCP) encoded by SLC10A1 was recently demonstrated to be a functional receptor for hepatitis B virus (HBV). The role of SLC10A1 polymorphisms, particularly the Ser267Phe variant (rs2296651) in exon 4, has been frequently investigated in regard to risk of persistent HBV infection. However, these investigations have generated conflicting results. To examine whether common genetic variation at the SLC10A1 locus is associated with risk of persistent HBV infection, haplotype-tagging and imputed single nucleotide polymorphisms (SNPs) were assessed in two case-control sample sets, totally including 2,550 cases (persistently HBV infected subjects, PIs) and 2,124 controls (spontaneously recovered subjects, SRs) of Southern Chinese ancestry. To test whether rare or subpolymorphic SLC10A1 variants are associated with disease risk, the gene's exons in 244 cases were sequenced. Overall, we found neither SNPs nor haplotypes of SLC10A1 showed significant association in the two sample sets. Furthermore, no significant associations of rare variants or copy number variation covering SLC10A1 were observed. Finally, expression quantitative trait locus analyses revealed that SNPs potentially affecting SLC10A1 expression also showed no significant associations. We conclude that genetic variation at the SLC10A1 locus is not likely a major risk factor of persistent HBV infection among Southern Chinese.

PMID:
28429786
PMCID:
PMC5399367
DOI:
10.1038/srep46490
[Indexed for MEDLINE]
Free PMC Article

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