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Bull Exp Biol Med. 2017 Apr;162(6):750-753. doi: 10.1007/s10517-017-3704-3. Epub 2017 Apr 21.

Combined Effects of M1 Muscarinic Acetylcholine Receptor Agonist TBPB and α7n-Acetylcholine Receptor Activator GTS-21 on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis.

Author information

1
Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia. pfzabrodsky@gmail.com.
2
Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia.

Abstract

Experiments on random-bred albino mice showed that M1 muscarinic acetylcholine receptor agonist (TBPB) and α7n-acetylcholine receptor agonist (GTS-21) significantly reduced mortality of mice with experimental sepsis (intraperitoneally administration of E. coli) in 4 and 24 h after modeling by reducing blood concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6. Combined treatment with TBPB and GTS-21 determined their additive effect.

KEYWORDS:

M1-acetylcholine receptors; cholinergic anti-inflammatory pathway; proinflammatory cytokines; sepsis; α7n-acetylcholine receptors

PMID:
28429224
DOI:
10.1007/s10517-017-3704-3
[Indexed for MEDLINE]

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