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Bull Exp Biol Med. 2017 Apr;162(6):734-737. doi: 10.1007/s10517-017-3700-7. Epub 2017 Apr 20.

Analysis of Gut Microbiota in Patients with Parkinson's Disease.

Author information

1
Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia. vyacheslav.a.petrov@mail.ru.
2
Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
3
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russia.
4
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
5
M. V. Lomonosov Moscow State University, Moscow, Russia.

Abstract

Gut microbiota of patients with Parkinson's disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson's diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.

KEYWORDS:

16S rRNA sequencing; Parkinson’s disease; gut microbiota

PMID:
28429209
DOI:
10.1007/s10517-017-3700-7
[Indexed for MEDLINE]

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