Format

Send to

Choose Destination
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:185-193. doi: 10.1016/j.pnpbp.2017.04.016. Epub 2017 Apr 18.

The correlation between mood states and functional connectivity within the default mode network can differentiate Internet gaming disorder from healthy controls.

Author information

1
Department of Psychology, Zhejiang Normal University, Jinhua, PR China; Institute of Psychological and Brain Sciences, Zhejiang Normal University, Jinhua, China. Electronic address: dongguangheng@zjnu.edu.cn.
2
Department of Psychology, Zhejiang Normal University, Jinhua, PR China.
3
Department of Psychiatry, Child Study Center, and the National Center on Addiction and Substance Abuse (CASAColumbia), Yale University School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: marc.potenza@yale.edu.

Abstract

The default-mode network (DMN) has been suggested to support a baseline state of brain activity. However, whether connectivity within the DMN is associated with mood states remains incompletely understood. The current study examined the correlation between mood state and the functional connectivity (FC) among DMN regions, and examined if the FC can differentiate Internet gaming disorder (IGD) from healthy controls (HC). Resting state data were collected within 108 college students (IGD,41; HC,67). Negative correlations were observed between measures of: (1) Depression and FCs among ventral DMN regions; (2) Anger and FCs among dorsal DMN regions; and, (3) Anger and Depression and FCs of both the ventral and dorsal DMN. The results suggest that negative mood states of Depression and Anger might reflect poorer, or might impair, FCs among DMN regions. In addition, the FC among DMNs could be useful indexes in differencing IGD from HC. Future studies should examine the extent to which the findings may extend to clinical populations and whether increased connectivity of DMN regions may represent a mechanism for reducing negative mood states.

KEYWORDS:

Default mode network; Functional connectivity; Mood state; Resting states fMRI

PMID:
28428146
DOI:
10.1016/j.pnpbp.2017.04.016
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center