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Clin Immunol. 2017 Sep;182:48-54. doi: 10.1016/j.clim.2017.04.005. Epub 2017 Apr 17.

Sjogren's syndrome: Clinical aspects.

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Division of Rheumatology, Penn Presbyterian Medical Center, United States; Penn Sjogren's Syndrome Center, Perelman School of Medicine, University of Pennsylvania, United States.


Sjogren's syndrome (SS) is the 2nd most common chronic autoimmune rheumatic disease and associated with a high burden of illness. Morbidity arises not only from untreated xerostomia and keratoconjunctivitis sicca but also from extra-glandular manifestations including the development of non-Hodgkin's B cell lymphomas. Proper diagnosis of SS requires objective evidence of dry eyes and/or objective evidence of dry mouth as well as proof of autoimmunity. The recent development of new international classification criteria and clinical practice guidelines for SS should not only enhance the existing standards of care but also facilitate further studies to improve future diagnosis and outcomes.

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