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Neurosci Lett. 2017 May 22;650:60-64. doi: 10.1016/j.neulet.2017.04.027. Epub 2017 Apr 18.

Plasma neurofilament light chain levels in Alzheimer's disease.

Author information

1
Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
2
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: drzhangj@yahoo.com.
3
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
4
Xujiahui community health service center,Xuhui District, Shanghai, China.
5
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
6
The Affiliated High School to Hangzhou Normal University, Hangzhou, China.
7
Beijing HuiLongGuan Hospital, Peking University, Beijing, China. Electronic address: zhangxy9@gmail.com.

Abstract

Plasma neurofilament light (NFL) levels may be a marker of neuronal injury. We examined whether plasma NFL might be a potential biomarker for the prodromal and dementia stages of AD. Participants included 193 cognitively normal (CN), 198 amnestic mild cognitive impairment (aMCI) and 187 Alzheimer's disease (AD) individuals enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Plasma NFL levels were examined by the Single Molecule array (Simoa) technique. Our results showed significantly increased plasma NFL levels in both AD (50.9pg/ml) and aMCI (43.0pg/ml) groups compared to CN (34.7pg/ml) group (both p<0.001), but with substantial overlap between the groups. Plasma NFL levels in AD group was also markedly increased, compared with aMCI group (p<0.001). Plasma NFL levels were positively associated with age (r=0.355, p<0.001) and negatively with global cognition (r=-0.355, p<0.001) in all subjects. Our results suggest that plasma NFL levels may not be a useful biomarker for the diagnosis of prodromal and dementia stages of AD.

KEYWORDS:

Alzheimer’disease; Biomarker; Mild cognitive impairment; Neurofilament light

PMID:
28428015
DOI:
10.1016/j.neulet.2017.04.027
[Indexed for MEDLINE]

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