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Neurosci Lett. 2017 May 22;650:52-59. doi: 10.1016/j.neulet.2017.04.026. Epub 2017 Apr 17.

Concussion induces focal and widespread neuromorphological changes.

Author information

1
Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Canada.
2
Division of Neurosurgery, Sunnybrook Hospital, Toronto, Canada.
3
Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada; Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Canada.
4
Neurology, The Hospital for Sick Children, Toronto, Canada.
5
Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada.
6
Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada; Department of Medical Imaging, University of Toronto, Toronto, Canada. Electronic address: ben.dunkley@sickkids.ca.

Abstract

Concussion induces transient, and oftentimes chronic, lingering impairment to mental functioning, which must be driven by some underlying neurobiological perturbation - however, the physical changes related to sequelae are difficult to detect. Previous imaging studies on concussion have focused on alterations to cortical anatomy, but few have examined the cerebrum, subcortex, and cerebellum. Here, we present an analysis of these structures in a single cohort (all males, 21 patients, 22 controls) using MRI and diagnosed with a single-concussive episode in the acute and sub-acute stages of injury. Structural images were segmented into 78 cortical brain regions and 81,924 vertices using the CIVET algorithm. Subcortical volumetric analyses of the cerebellum, thalamus, globus pallidus, caudate and putamen were conducted following segmentation. Participants with concussion were found to have reduced white and grey matter volume, total cortical volume, as well as cortical thinning, primarily in left frontal areas. No differences were observed in the cerebellum or subcortical structures. In conclusion, just a single concussive episode induces measurable changes in brain structure manifesting as diffuse and local patterns of altered neuromorphometry.

KEYWORDS:

Cerebellum; Concussion; Cortical thickness; Cortical volume; MRI

PMID:
28428014
DOI:
10.1016/j.neulet.2017.04.026
[Indexed for MEDLINE]
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