Format

Send to

Choose Destination
See comment in PubMed Commons below
Adv Food Nutr Res. 2017;82:83-116. doi: 10.1016/bs.afnr.2017.01.001. Epub 2017 Feb 13.

Metabolomics, Nutrition, and Potential Biomarkers of Food Quality, Intake, and Health Status.

Author information

1
INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, France; Laboratoire de Nutrition Humaine, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 321, Clermont-Ferrand, France. Electronic address: jean-louis.sebedio@clermont.inra.fr.

Abstract

Diet, dietary patterns, and other environmental factors such as exposure to toxins are playing an important role in the prevention/development of many diseases, like obesity, type 2 diabetes, and consequently on the health status of individuals. A major challenge nowadays is to identify novel biomarkers to detect as early as possible metabolic dysfunction and to predict evolution of health status in order to refine nutritional advices to specific population groups. Omics technologies such as genomics, transcriptomics, proteomics, and metabolomics coupled with statistical and bioinformatics tools have already shown great potential in this research field even if so far only few biomarkers have been validated. For the past two decades, important analytical techniques have been developed to detect as many metabolites as possible in human biofluids such as urine, blood, and saliva. In the field of food science and nutrition, many studies have been carried out for food authenticity, quality, and safety, as well as for food processing. Furthermore, metabolomic investigations have been carried out to discover new early biomarkers of metabolic dysfunction and predictive biomarkers of developing pathologies (obesity, metabolic syndrome, type-2 diabetes, etc.). Great emphasis is also placed in the development of methodologies to identify and validate biomarkers of nutrients exposure.

KEYWORDS:

Biomarkers; Epidemiology; Food quality; Human intervention; Metabolic dysfunction; Metabolomics; Nutrition; Omic technologies

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center