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BMC Complement Altern Med. 2017 Apr 20;17(1):222. doi: 10.1186/s12906-017-1734-z.

HVC1 ameliorates hyperlipidemia and inflammation in LDLR-/- mice.

Author information

1
College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do, 26339, Republic of Korea.
2
Catholic Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.
3
Department of Herbology, College of Korean Medicine, Kyung hee University, Seoul, 02447, Republic of Korea.
4
Department of Rehabilitation Medicine of Korean Medicine and Neuropsychiatry, College of Oriental Medicine, Sangji University, Wonju-si, Gangwon-do, 26339, Republic of Korea.
5
College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do, 26339, Republic of Korea. hjan@sj.ac.kr.

Abstract

BACKGROUND:

HVC1 consists of Coptidis Rhizoma (dried rhizome of Coptischinensis), Scutellariae Radix (root of Scutellariabaicalensis), Rhei Rhizoma (rhizome of Rheum officinale), and Pruni Cortex (cortex of Prunusyedoensis Matsum). Although the components are known to be effective in various conditions such as inflammation, hypertension, and hypercholesterolemia, there are no reports of the molecular mechanism of its hypolipidemic effects.

METHODS:

We investigated the hypolipidemic effect of HVC1 in low-density lipoprotein receptor-deficient (LDLR-/-) mice fed a high-cholesterol diet for 13 weeks. Mice were randomized in to 6 groups: ND (normal diet) group, HCD (high-cholesterol diet) group, and treatment groups fed HCD and treated with simvastatin (10 mg/kg, p.o.) or HVC1 (10, 50, or 250 mg/kg, p.o.).

RESULTS:

HVC1 regulated the levels of total cholesterol, triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol in mouse serum. In addition, it regulated the transcription level of the peroxisome proliferator-activated receptors (PPARs), sterol regulatory element-binding proteins (SREBP)-2, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, lipoprotein lipase (LPL), apolipoprotein B (apo B), liver X receptor (LXR), and inflammatory cytokines (IL-1β, IL-6, and TNF-α). Furthermore, HVC1 activated 5' adenosine monophosphate-activated protein kinase (AMPK).

CONCLUSION:

Our results suggest that HVC1 might be effective in preventing high-cholesterol diet-induced hyperlipidemia by regulating the genes involved in cholesterol and lipid metabolism, and inflammatory responses.

KEYWORDS:

AMPK; HVC1; Hyperlipidemia; Inflammatory cytokine; LDLR−/−; PPAR

PMID:
28427397
PMCID:
PMC5397752
DOI:
10.1186/s12906-017-1734-z
[Indexed for MEDLINE]
Free PMC Article

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