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Environ Res. 2017 Jul;156:505-511. doi: 10.1016/j.envres.2017.04.015. Epub 2017 Apr 26.

Urinary triclosan concentrations during pregnancy and birth outcomes.

Author information

1
Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Electronic address: Taylor_Etzel@brown.edu.
2
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
3
Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, OH, USA.
4
Faculty of Health Sciences, Simon Fraser University, Burnaby, B.C., Canada.
5
Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
6
Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Abstract

BACKGROUND:

Triclosan is an antimicrobial chemical used in consumer products, and exposure is ubiquitous among pregnant women in the United States. Triclosan may reduce the levels of thyroid hormones that are important for fetal growth and development.

OBJECTIVE:

We investigated the relationship of prenatal triclosan exposure with birth anthropometry and gestational duration.

METHODS:

We used data from 378 mother-child pairs participating in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort from Cincinnati, OH. We measured triclosan concentrations in maternal urine samples collected at 16 and 26 weeks of pregnancy. We abstracted information on neonatal anthropometry and gestational duration from medical records. We used multivariable linear regression to estimate the covariate-adjusted association between the average of the two urinary triclosan concentrations and gestational age standardized weight z-score, length, head circumference, and gestational age at birth.

RESULTS:

Median urinary triclosan concentrations were 16ng/mL (range: <2.4 to 1501ng/mL). Each 10-fold increase in triclosan was associated with a predicted 0.15 standard deviation decrease (95% CI: -0.30, 0.00) in birth weight z-score, 0.4-cm decrease (95% CI: -0.8, 0.1) in birth length, 0.3-cm decrease (95% CI: -0.5, 0.0) in head circumference, and 0.3-week decrease (95% CI: -0.6, -0.1) in gestational age. Child sex did not modify the associations between triclosan and birth outcomes.

CONCLUSIONS:

In this cohort, maternal urinary triclosan concentrations during pregnancy were inversely associated with infants' birth weight, length, head circumference, and gestational age.

KEYWORDS:

Birth weight; Epidemiology; Prenatal; Triclosan

PMID:
28427038
PMCID:
PMC5495558
DOI:
10.1016/j.envres.2017.04.015
[Indexed for MEDLINE]
Free PMC Article

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