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Stem Cell Res. 2017 May;21:94-105. doi: 10.1016/j.scr.2017.04.003. Epub 2017 Apr 8.

Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence.

Author information

1
Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA; Department of Genetics and Evolution, Federal University of São Carlos, São Carlos 13565-905, Brazil.
2
Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA; Department of Oral Pathology, School of Dentistry, University of Sao Paulo, SP 05508-000, Brazil.
3
Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil.
4
Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
5
Department of Otolaryngology, Medical School, University of Michigan, Ann Arbor, MI, USA; Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
6
Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: rcastilh@umich.edu.
7
Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.

KEYWORDS:

Adenoid cystic carcinoma; Cancer stem cells; Chemoresistance; Cisplatin; Vorinostat

PMID:
28426972
DOI:
10.1016/j.scr.2017.04.003
[Indexed for MEDLINE]
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