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Fly (Austin). 2017 Oct 2;11(4):253-259. doi: 10.1080/19336934.2017.1321181. Epub 2017 Apr 20.

The absence of crossovers on chromosome 4 in Drosophila melanogaster: Imperfection or interesting exception?

Author information

1
a Curriculum in Genetics and Molecular Biology , University of North Carolina , Chapel Hill , North Carolina , USA.
2
b Department of Biology , University of North Carolina , Chapel Hill , North Carolina , USA.
3
c Integrative Program for Biological and Genome Sciences , University of North Carolina , Chapel Hill , North Carolina , USA.

Abstract

Drosophila melanogaster chromosome 4 is an anomaly because of its small size, chromatin structure, and most notably its lack of crossing over during meiosis. Earlier ideas about the absence of crossovers on 4 hypothesize that these unique characteristics function to prevent crossovers. Here, we explore hypotheses about the absence of crossovers on 4, how these have been addressed, and new insights into the mechanism behind this suppression. We review recently published results that indicate that global crossover patterning, in particular the centromere effect, make a major contribution to the prevention of crossovers on 4.

KEYWORDS:

Bloom syndrome helicase; chromosome 4; crossover patterning; meiosis; recombination

PMID:
28426351
PMCID:
PMC5721948
DOI:
10.1080/19336934.2017.1321181
[Indexed for MEDLINE]
Free PMC Article

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