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Curr Pharm Des. 2017;23(20):2918-2929. doi: 10.2174/1381612823666170419105413.

Targeted Drug Delivery Based on Gold Nanoparticle Derivatives.

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Department of Tissue Engineering & Regenerative Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran. Iran.
Biomaterials Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran. Iran.
Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz. Iran.
Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran. Iran.
Division of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center, Columbia University, New York, NY. United States.
Nanotechnology and Regenerative Medicine Ltd, The London BioScience Innovation Centre, London. United Kingdom.


Drug delivery systems are effective and attractive methods which allow therapeutic substances to be introduced into the body more effectively and safe by having tunable delivery rate and release target site. Gold nanoparticles (AuNPs) have a myriad of favorable physical, chemical, optical, thermal and biological properties that make them highly suitable candidates as non-toxic carriers for drug and gene delivery. The surface modifications of AuNPs profoundly improve their circulation, minimize aggregation rates, enhance attachment to therapeutic molecules and target agents due to their nano range size which further increases their ability to cross cell membranes and reduce overall cytotoxicity. This comprehensive article reviews the applications of the AuNPs in drug delivery systems along with their corresponding surface modifications. The highlighting results obtained from the preclinical trial are promising and next five years have huge possibility move to the clinical setting.


Gold nanoparticle; drug delivery; nanoparticles; nanotechnology; surface modification; targeted delivery

[Indexed for MEDLINE]

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