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Adipocyte. 2017 Apr 3;6(2):134-140. doi: 10.1080/21623945.2017.1287639. Epub 2017 Jan 27.

Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery.

Author information

1
a Department of Pediatrics and Communicable Diseases , University of Michigan Medical School , Ann Arbor , MI , USA.
2
e Graduate Program in Immunology , University of Michigan Medical School , Ann Arbor , MI , USA.
3
b Department of Surgery , University of Michigan Medical School , Ann Arbor , MI , USA.
4
c Undergraduate Research Opportunity Program , University of Michigan , Ann Arbor , MI , USA.
5
d Department of Surgery , Ann Arbor Veteran's Administration Hospital , Ann Arbor , MI , USA.
6
f Graduate Program in Cellular and Molecular Biology , University of Michigan Medical School , Ann Arbor , MI , USA.

Abstract

Predictors of weight loss responses are not well-defined. We hypothesized that adipose tissue phenotypic features related to remodeling would be associated with bariatric surgery weight loss responses. Visceral and subcutaneous adipose tissues collected from patients during bariatric surgery were studied with flow cytometry, immunohistochemistry, and QRTPCR, and results correlated with weight loss outcomes. Age, male sex, and a diagnosis of type 2 diabetes were associated with less weight loss. Adipocyte size was increased and preadipocyte frequency was decreased in visceral adipose tissue from diabetic subjects. Decreased adipose tissue preadipocyte frequency was associated with less weight loss in women but not men. These data suggest that phenotypic features of adipose tissue remodeling may predict responses to weight loss interventions.

KEYWORDS:

adipose tissue; bariatric surgery; diabetes; hypertrophy; preadipocyte; weight loss

PMID:
28425841
PMCID:
PMC5477697
DOI:
10.1080/21623945.2017.1287639
[Indexed for MEDLINE]
Free PMC Article

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