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J Mol Evol. 1988;27(2):102-8.

Structure of the human hemopexin gene and evidence for intron-mediated evolution.

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1
Cattedra di Biologia Generale, Torino, Italy.

Abstract

The human hemopexin gene was isolated and its structure determined. The gene spans approximately 12 kb and is interrupted by nine introns. When the intron/exon pattern was examined with respect to the polypeptide segments they encode, a direct correspondence between exons and the 10 repeating units in the protein was observed. The introns are not randomly placed; they fall in the middle of the region of amino acid sequence homology in strikingly similar locations in 6 of the 10 units and in a symmetrical position in the two halves of the coding sequence. These features strongly support the hypothesis that the gene evolved through intron-mediated duplications of a primordial sequence to a five-exon cluster. A more recent gene duplication led to the present-day gene organization.

PMID:
2842511
[Indexed for MEDLINE]
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