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Nature. 2017 Apr 27;544(7651):434-439. doi: 10.1038/nature22074. Epub 2017 Apr 19.

The genetic basis of parental care evolution in monogamous mice.

Bendesky A1,2,3, Kwon YM1,2, Lassance JM1,2,3, Lewarch CL1,3, Yao S1,3, Peterson BK1,2, He MX4, Dulac C1,3,5, Hoekstra HE1,2,3,4,5,6.

Author information

1
Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA.
2
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
3
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
4
Graduate Program in Biophysics, Harvard University, Cambridge, Massachusetts 02138, USA.
5
Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA.
6
Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

Parental care is essential for the survival of mammals, yet the mechanisms underlying its evolution remain largely unknown. Here we show that two sister species of mice, Peromyscus polionotus and Peromyscus maniculatus, have large and heritable differences in parental behaviour. Using quantitative genetics, we identify 12 genomic regions that affect parental care, 8 of which have sex-specific effects, suggesting that parental care can evolve independently in males and females. Furthermore, some regions affect parental care broadly, whereas others affect specific behaviours, such as nest building. Of the genes linked to differences in nest-building behaviour, vasopressin is differentially expressed in the hypothalamus of the two species, with increased levels associated with less nest building. Using pharmacology in Peromyscus and chemogenetics in Mus, we show that vasopressin inhibits nest building but not other parental behaviours. Together, our results indicate that variation in an ancient neuropeptide contributes to interspecific differences in parental care.

PMID:
28424518
PMCID:
PMC5600873
DOI:
10.1038/nature22074
[Indexed for MEDLINE]
Free PMC Article

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