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Biosci Rep. 2017 Apr 19. pii: BSR20170286. doi: 10.1042/BSR20170286. [Epub ahead of print]

Dietary capsaicin and its anti-obesity potency: From mechanism to clinical implications.

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Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, Massachusetts, 100730, China.
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Peking Union Medical College Hospital, Beijing, Massachusetts, 100730, China.
Peking Union Medical College Hospital, Beijing, China


Obesity is a growing public health problem, which has now been considered as a pandemic non-communicable disease. However, the efficacy of several approaches for weight loss is limited and variable. Thus, alternative anti-obesity treatments are urgently warranted, which should be effective, safe and widely available. Active compounds isolated from herbs are similar with the practice of Traditional Chinese Medicine, which has a holistic approach that can targets to several organs and tissues in the whole body. Capsaicin, a major active compound from chili peppers, has been clearly demonstrated for its numerous beneficial roles in health. In this review, we will focus on the a less highlighted aspect, in particular how dietary chili peppers and capsaicin consumption reduce body weight and its potential mechanisms of its anti-obesity effects. With the widespread pandemic of overweight and obesity, the development of more strategies for the treatment of obesity is urgent. Therefore, a better understanding of the role and mechanism of dietary capsaicin consumption and metabolic health can provide critical implications for the early prevention and treatment of obesity.


Capsaicin; TRPV1; adipogenesis; appetite; obesity; rown adipose tissue

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