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An Acad Bras Cienc. 2017 Jan-Mar;89(1):285-299. doi: 10.1590/0001-3765201720160487.

Immune System Dysfunction in the Elderly.

Author information

1
Platelet Research Laboratory, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging/ PIEI-ES, Universidad de Talca, Postal Code 3460000, Casilla 747, Talca, Chile.
2
Núcleo Científico Multidisciplinario, Universidad de Talca, Postal Code 3460000, Casilla 747, Talca, Chile.

Abstract

Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this function is unclear. In this article the function of the immune system during aging is explored.

PMID:
28423084
DOI:
10.1590/0001-3765201720160487
[Indexed for MEDLINE]
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