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J Am Geriatr Soc. 2017 Oct;65(10):2134-2139. doi: 10.1111/jgs.14902. Epub 2017 Apr 19.

Integrating Frailty Research into the Medical Specialties-Report from a U13 Conference.

Author information

1
Division of Geriatric Medicine and Frailty, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
2
Department of Surgery, Denver Veterans Affairs Medical Center, Denver, Colorado.
3
Division of Geriatrics and Clinical Gerontology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
4
Science/Medical Writer, Independent Consultant, Annapolis, Maryland.
5
Department of Emergency Medicine, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
6
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
7
Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia.
8
Division of Geriatric Medicine and Palliative Care, Department of Medicine, New York University, New York City, New York.
9
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York City, New York.
10
Division of Geriatric Psychiatry, Program on Healthy Aging and Late Life Brain Disorders, New York State Psychiatric Institute, New York City, New York.
11
Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland.
12
Division of Pulmonary and Critical Care and Health Services Research, Department of Veterans Affairs Nashville, Vanderbilt University and Geriatric Research, Education and Clinical Center, Nashville, Tennessee.
13
Wake Forest Baptist Health, Winston-Salem, North Carolina.
14
Sticht Center for Healthy Aging and Alzheimer's Prevention, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
15
Center for the Study of Aging, Duke University Medical Center, Durham, North Carolina.
16
Geriatric Research, Education and Clinical Center, Durham Veterans Affairs Medical Center, Durham, North Carolina.
17
Division of Aging Biology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
18
Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University, Baltimore, Maryland.
19
Department of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, California.

Abstract

Although the field of frailty research has expanded rapidly, it is still a nascent concept within the clinical specialties. Frailty, conceptualized as greater vulnerability to stressors because of significant depletion of physiological reserves, predicts poorer outcomes in several medical specialties, including cardiology, human immunodeficiency virus care, and nephrology, and in the behavioral and social sciences. Lack of a consensus definition, proliferation of measurement tools, inadequate understanding of the biology of frailty, and lack of validated clinical algorithms for frail individuals hinders incorporation of frailty assessment and frailty research into the specialties. In 2015, the American Geriatrics Society, the National Institute on Aging (NIA), and the Alliance for Academic Internal Medicine held a conference for awardees of the NIA-sponsored Grants for Early Medical/Surgical Specialists Transition into Aging Research program to review the current state of knowledge regarding frailty in the subspecialties and to highlight examples of integrating frailty research into the medical specialties. Research questions to advance frailty research into specialty medicine are proposed.

KEYWORDS:

biologic mechanisms; clinical manifestations; frailty; measurement; medical specialties

PMID:
28422280
PMCID:
PMC5641231
DOI:
10.1111/jgs.14902
[Indexed for MEDLINE]
Free PMC Article

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