Format

Send to

Choose Destination
J Paediatr Child Health. 2017 Jul;53(7):680-684. doi: 10.1111/jpc.13540. Epub 2017 Apr 19.

Empiric antibiotic regimens for neonatal sepsis in Australian and New Zealand neonatal intensive care units.

Author information

1
Department of Infection and Immunity, Monash Children's Hospital, Melbourne, Victoria, Australia.
2
Department of Paediatrics, School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia.
3
Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
4
Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
5
The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.

Abstract

AIM:

Neonatal sepsis remains an important cause of morbidity and mortality, and requires prompt empiric treatment. However, only a minority of babies who receive antibiotics for suspected sepsis have an infection. Antimicrobial exposure in infancy has important short- and long-term consequences. There is no consensus regarding empirical antimicrobial regimens.

METHODS:

The study included a survey of empiric antimicrobial regimens in all tertiary neonatal intensive care units in Australia and New Zealand in 2013-2014.

RESULTS:

All 27 units responded. For early-onset sepsis, all units used a combination of gentamicin with either penicillin or ampicillin. For late-onset sepsis, the frequency of units using empiric vancomycin (41%) versus empiric flucloxacillin (48%) was similar. Gestational age or the presence of a central venous catheter had little influence on using vancomycin instead of flucloxacillin. For late-onset sepsis with meningitis there was marked variation in antimicrobial combinations, with 15 different regimens described. A total of 93% used a cefotaxime-based regimen, either as monotherapy (22%) or combined with a second (22%) or third (48%) agent. For suspected necrotising enterocolitis, 89% used an aminoglycoside, metronidazole and a penicillin. Historical outbreaks of multi-resistant organisms exerted long-term influence over regimen choice.

CONCLUSIONS:

There was limited use of broad-spectrum agents such as carbapenems or third-generation cephalosporins. In this region with low methicillin-resistant Staphylococcus aureus prevalence, empiric vancomycin use was common, selected for activity against coagulase-negative staphylococci. Empiric vancomycin is rarely necessary because coagulase-negative staphylococci are often contaminants and sepsis is rarely fulminant, occurring almost exclusively in extremely low birthweight infants. Implementation of appropriate, local antimicrobial policies is crucial to minimise antimicrobial exposure in this vulnerable population and halt the development of antimicrobial resistance.

KEYWORDS:

infectious diseases; intensive care; neonatology

PMID:
28421643
DOI:
10.1111/jpc.13540
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center