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MBio. 2017 Apr 18;8(2). pii: e00354-17. doi: 10.1128/mBio.00354-17.

Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells.

Author information

1
Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.
2
Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA twood@engr.psu.edu.

Abstract

There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and growing cell populations (e.g., as a result of nutrient shifts) and attributing the phenotypes that they discern to persister cells while other labs are studying dormant cells. We argue here that the metabolically active cell population should more accurately be considered tolerant cells, while the dormant cells are the true persister population.

KEYWORDS:

antimicrobial agents; persistence; tolerance

PMID:
28420737
PMCID:
PMC5395667
DOI:
10.1128/mBio.00354-17
[Indexed for MEDLINE]
Free PMC Article

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