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Cancers (Basel). 2017 Apr 15;9(4). pii: E34. doi: 10.3390/cancers9040034.

AR Signaling and the PI3K Pathway in Prostate Cancer.

Author information

1
Kinghorn Cancer Centre, St Vincent's Hospital, 370 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. m.crumbaker@garvan.org.au.
2
Garvan Institute of Medical Research, St Vincent's Clinical School, University of New South Wales, Sydney, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia. m.crumbaker@garvan.org.au.
3
AstraZeneca UK, Clinical Discovery Unit, Early Clinical Development Innovative Medicines, da Vinci Building, Melbourn Science Park, Melbourn, Hertfordshire SG8 6HB, UK. lkhoja@yahoo.com.
4
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust Cambridge Biomedical Campus, Hills Rd, Cambridge CB2 0QQ, UK. lkhoja@yahoo.com.
5
Kinghorn Cancer Centre, St Vincent's Hospital, 370 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. anthony.joshua@svha.org.au.
6
Garvan Institute of Medical Research, St Vincent's Clinical School, University of New South Wales, Sydney, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia. anthony.joshua@svha.org.au.
7
Princess Margaret Cancer Centre, University Health Network, University of Toronto, University Avenue, Toronto, ON M5G 2M9, Canada. anthony.joshua@svha.org.au.

Abstract

Prostate cancer is a leading cause of cancer-related death in men worldwide. Aberrant signaling in the androgen pathway is critical in the development and progression of prostate cancer. Despite ongoing reliance on androgen receptor (AR) signaling in castrate resistant disease, in addition to the development of potent androgen targeting drugs, patients invariably develop treatment resistance. Interactions between the AR and PI3K pathways may be a mechanism of treatment resistance and inhibitors of this pathway have been developed with variable success. Herein we outline the role of the PI3K pathway in prostate cancer and, in particular, its association with androgen receptor signaling in the pathogenesis and evolution of prostate cancer, as well as a review of the clinical utility of PI3K targeting.

KEYWORDS:

AR signaling; PI3K; castrate resistant prostate cancer; prostate cancer

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