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Biomed Pharmacother. 2017 Jun;90:713-723. doi: 10.1016/j.biopha.2017.04.022. Epub 2017 Apr 15.

Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro.

Author information

1
Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey.
2
Department of Neurosurgery, Medical Faculty, Uludag University, Bursa, Turkey.
3
Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey. Electronic address: btunca@uludag.edu.tr.
4
Department of Pathology, Medical Faculty, Uludag University, Bursa, Turkey.

Abstract

Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p=0.0001, p<0.001, p=0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM.

KEYWORDS:

Angiogenesis; Glioblastoma cancer stem cell; Invasion; MMP2; MMP9; Olea europaea leaf extract; VEGFA

PMID:
28419967
DOI:
10.1016/j.biopha.2017.04.022
[Indexed for MEDLINE]

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