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J Cutan Pathol. 2017 Jun;44(6):557-562. doi: 10.1111/cup.12952.

Well-differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63.

Author information

1
Department of Dermatology, Division of Dermatopathology, Yale School of Medicine, New Haven, Connecticut.
2
Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
3
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Abstract

BACKGROUND:

Well-differentiated neuroendocrine tumors (WDNETs) in skin include metastases from visceral primary sites and very uncommonly, primary cutaneous carcinoid tumors. Cutaneous WDNET may present a diagnostic challenge and in particular can be mistaken for a benign skin adnexal tumor. In contrast to cutaneous adnexal tumors, metastatic adenocarcinomas to the skin are cytokeratin 5/6 (CK5/6) and p63 negative in the majority of cases. It is unclear if failure to stain with CK5/6 and p63 would be helpful in differentiating WDNETs from cutaneous adnexal neoplasms.

METHODS:

We reviewed 10 cases of cutaneous WDNETs (8 cases of metastatic disease and 2 presumed primary carcinoid tumors of the skin) and performed immunohistochemical stains for CK5/6 and p63 on all cases.

RESULTS:

All 10 cases were negative with both CK5/6 and p63.

CONCLUSION:

Negative staining for CK5/6 and p63 can be helpful to distinguish WDNETs from cutaneous adnexal neoplasms. It is important to consider WDNETs in the differential diagnosis of cutaneous adnexal neoplasms as low-grade tumors may be the first sign of aggressive metastatic disease.

KEYWORDS:

CK5/6; cutaneous carcinoid; p63; well-differentiated neuroendocrine tumor

PMID:
28417484
DOI:
10.1111/cup.12952
[Indexed for MEDLINE]

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