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Respir Med Case Rep. 2017 Apr 6;21:84-85. doi: 10.1016/j.rmcr.2017.03.024. eCollection 2017.

Progressive dyspnea due to pulmonary carcinoid tumorlets.

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Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Oncology Department, Interbalkan European Medical Center, Thessaloniki, Greece.
Surgery Department, Interbalkan European Medical Center, Thessaloniki, Greece.
Oncology Department, "G. Papageorgiou" University General Hospital, Aristotle University of Thessaloniki, Greece.
Department of Respiratory and Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Sana Clinic Group Franken, Department of Cardiology / Pulmonology / Intensive Care / Nephrology, "Hof" Clinics, University of Erlangen, Hof, Germany.


This is a case description of a female patient, 77 years-old, who presented with progressive dyspnea and cough. She had a mild hypoxemia in the arterial blood gases (PaO2 72 mmHg) and normal spirometry. The chest computer tomography revealed diffuse "ground glass" opacities, segmental alveolitis, bronchiectasis, fibrotic lesions and numerous micronodules. A thoracoscopy was performed and the obtained biopsy showed carcinoid tumorlets, with positive CK8/18, CD56, TTF-1 and synaptophysin immunohistochemical markers. Pulmonary carcinoid tumorlets are rare, benign lesions and individuals with tumorlets are typically asymptomatic. Our report presents a symptomatic clinical case of carcinoid tumorlet.


Dyspnea; Neuroendocrine lung cells hyperplasia; Nodules; Pulmonary carcinoid tumorlet

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