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Oncotarget. 2017 May 2;8(18):29823-29832. doi: 10.18632/oncotarget.16161.

Salicylate •Phenanthroline copper (II) complex induces apoptosis in triple-negative breast cancer cells.

Fan L1,2, Tian M3, Liu Y1,2, Deng Y1,2, Liao Z3,4, Xu J1,2.

Author information

1
School of Medicine, Jianghan University, Wuhan, Hubei 430056, China.
2
Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, Jianghan University, Wuhan, Hubei 430056, China.
3
Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China.
4
Hubei Key Laboratory of Tumor Biological Behavior, Wuhan University, Wuhan, Hubei 430071, China.

Abstract

In this study, we investigated anti-tumor activity and associated molecular mechanism of action of Salicylate ●Phenanthroline Copper (II) Complex in triple-negative breast cancer. Salicylate ●Phenanthroline Copper (II) Complex inhibited the growth of four breast cancer cell lines (MCF-7, T47D, MDA-MB-231 and BT-20) and induced apoptosis in a concentration-dependent manner. The effect was more profound in MDA-MB-231 and BT-20 triple-negative breast cancer cell lines. Western blot showed that the expression of the apoptosis-related protein Bcl-2, Bcl-xl and survivin was significantly reduced in MDA-MB-231 after treatment with Salicylate ●Phenanthroline Copper (II) Complex. In vivo, Salicylate ●Phenanthroline Copper (II) Complex administration significantly attenuated tumor growth of MDA-MB-231 xenografts, and the expression levels of Bcl-2, Bcl-xL and survivin were reduced as measured by immunohistochemical staining. These data suggest that Salicylate ●Phenanthroline Copper (II) Complex is a promising novel therapeutic drug for triple-negative breast cancer and warrants further study.

KEYWORDS:

Cu(sal)(phen); TNBC; anti-apoptotic protein; apoptosis; cell growth

PMID:
28415735
PMCID:
PMC5444706
DOI:
10.18632/oncotarget.16161
[Indexed for MEDLINE]
Free PMC Article

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