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Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:565-571. doi: 10.1016/j.msec.2017.02.066. Epub 2017 Feb 15.

Sustained release of simvastatin from hollow carbonated hydroxyapatite microspheres prepared by aspartic acid and sodium dodecyl sulfate.

Author information

1
Department of Pediatric Dentistry, the Affiliated Hospital of Stomatology, Jilin University, Changchun 130021, China.
2
College of Chemistry, Jilin University, Changchun 130021, China.
3
Department of Pediatric Dentistry, the Affiliated Hospital of Stomatology, Jilin University, Changchun 130021, China. Electronic address: lyi99@jlu.edu.cn.
4
Department of Stomatology, Children's Hospital of Changchun, 130051, China.
5
Department of Pediatric Dentistry, the Affiliated Hospital of Stomatology, Jilin University, Changchun 130021, China; Department of Pediatric Dentistry, Stomatological Hospital of Xiamen, 361003, China.

Abstract

Hollow carbonated hydroxyapatite (HCHAp) microspheres as simvastatin (SV) sustained-release vehicles were fabricated through a novel and simple one-step biomimetic strategy. Firstly, hollow CaCO3 microspheres were precipitated through the reaction of CaCl2 with Na2CO3 in the presence of aspartic acid and sodium dodecyl sulfate. Then, the as-prepared hollow CaCO3 microspheres were transformed into HCHAp microspheres with a controlled anion-exchange method. The HCHAp microspheres were 3-5μm with a shell thickness of 0.5-1μm and were constructed of short needle nanoparticles. The HCHAp microspheres were then loaded with SV, exhibiting excellent drug-loading capacity and sustained release properties. These results present a new material synthesis strategy for HCHAp microspheres and suggest that the as-prepared HCHAp microspheres are promising for applications in drug delivery.

KEYWORDS:

Drug release; Hollow carbonated hydroxyapatite; Microspheres; Simvastatin

PMID:
28415500
DOI:
10.1016/j.msec.2017.02.066
[Indexed for MEDLINE]

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