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Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:359-367. doi: 10.1016/j.msec.2017.02.068. Epub 2017 Feb 15.

Preparation of a novel bioavailable curcuminoid formulation (Cureit™) using Polar-Nonpolar-Sandwich (PNS) technology and its characterization and applications.

Author information

1
R&D Centre, Aurea Biolabs (P) Ltd, Kolenchery, Cochin, 682 311, Kerala, India.
2
R&D Centre, Aurea Biolabs (P) Ltd, Kolenchery, Cochin, 682 311, Kerala, India. Electronic address: sreeraj.gopi@plantlipids.com.
3
Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, P.O. Box 17011, Doornfontein, 2028 Johannesburg, South Africa; Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa.
4
School of Chemical Sciences, Mahatma Gandhi University, Kottayam, India.

Abstract

Health benefits of curcuminoid are highly limited due to their poor aqueous solubility, very low systemic bioavailability, fast metabolic alterations and rapid elimination. In this study, a novel bioavailable curcuminoid formulation Cureit™ was prepared by using Polar-Nonpolar-Sandwich (PNS) technology with complete natural turmeric matrix (CNTM). The synthesized bioavailable curcuminoid formulation Cureit™ was characterizations by Nuclear magnetic resonance spectroscopy (NMR), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infra-red (IR), current-voltage (I-V) study, Quadrupole Time-of-Flight Mass Spectrometry (Q-TOF), differential scanning calorimeter (DSC) and thermogravimetric analysis (TGA). NMR study showed the presence of hydrogen bonding interactions with curcuminoids, polar and non-polar compounds in the PNS technology. SEM images indicated that Cureit™ was almost spherical and well dispersed with rough morphology, and separated with three layers of PNS formulation. The chemical profile of Cureit™ was analyzed by Q-TOF confirmed the presence of curcuminoids (curcumin, demethoxycurcumin and bismethoxycurcumin), lactones, sesquiterpenes and their derivatives derived from polar layer, aromatic turmerone, dihydroturmerone, turmeronol, curdione and bisacurone derived from non-polar layer. IR, XRD, DSC and TGA also confirmed the presence of curcuminoids with high stability in the PNS formulation. Various biological activities of Cureit™ were also discussed.

KEYWORDS:

Bioavailability; Complete natural turmeric matrix; Curcuminoid; Cureit™; PNS technology

PMID:
28415473
DOI:
10.1016/j.msec.2017.02.068
[Indexed for MEDLINE]

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