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Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:286-296. doi: 10.1016/j.msec.2017.02.020. Epub 2017 Feb 10.

Photochemical coating of Kapton® with hydrophilic polymers for the improvement of neural implants.

Author information

1
Institute for Technical Chemistry, Braunschweig University of Technology, Germany. Electronic address: ch.hadler@tu-bs.de.
2
Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School, Germany.
3
Institute of Cell Biology in the Center of Anatomy, Hannover Medical School, Germany.
4
Institute for Technical Chemistry, Braunschweig University of Technology, Germany.
5
Institute for Technical Chemistry, Braunschweig University of Technology, Germany. Electronic address: h.menzel@tu-bs.de.

Abstract

The polyimide Kapton® was coated photochemically with hydrophilic polymers to prevent undesirable cell growth on the polyimide surface. The polymer coatings were generated using photochemically reactive polymers synthesized by a simple and modular strategy. Suitable polymers or previously synthesized copolymer precursors were functionalized with photoactive arylazide groups by a polymer analogous amide coupling reaction with 4-azidobenzoic acid. A photoactive chitosan derivative (chitosan-Az) and photochemically reactive copolymers containing DMAA, DEAA or MTA as primary monomers were synthesized using this method. The amount of arylazide groups in the polymers was adjusted to approximately 5%, 10% and 20%. As coating on Kapton® all polymers effect a significantly reduced water contact angle (WCA) and consequently a rise of the surface hydrophilicity compared to the untreated Kapton®. The presence of the polymer coatings was also proven by ATR-IR spectroscopy. Coatings with chitosan-Az and the DEAA copolymer cause a distinct inhibition of the growth of fibroblasts. In the case of the DMAA copolymer even a strong anti-adhesive behavior towards fibroblasts was verified. Biocompatibility of the polymer coatings was proven which enables their utilization in biomedical applications.

KEYWORDS:

Arylazide group; Cell adhesion; Fibroblast growth; Hydrophilic polymers; Photochemical polymer coating; Polyimide

PMID:
28415465
DOI:
10.1016/j.msec.2017.02.020
[Indexed for MEDLINE]

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