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J Reprod Med. 1988 Jun;33(6):503-9.

Intraepithelial and invasive neoplasia of the vulva in association with human papillomavirus infection.

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Department of Gynaecologic Oncology, Mercy Maternity Hospital, East Melbourne, Victoria, Australia.


Colposcopic examination of 335 women with cytologically detected human papillomavirus (HPV) revealed involvement of the cervix in 316 patients (94%), vagina in 276 (82%) and vulva in 148 (44%). A symptom complex of pruritus and superficial dyspareunia was found in 98 of the 148 patients with vulvar infection (66%). Histologic examination revealed HPV-associated vulvar intraepithelial neoplasia (VIN) in 11 of 148 biopsies (7.4%). Follow-up of the patients with HPV infection with or without VIN showed a spontaneous regression rate of 56% but also demonstrated progression to VIN 3 in two patients and to invasive carcinoma of the vulva in one.

[Indexed for MEDLINE]

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