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Behav Genet. 2017 Jul;47(4):425-433. doi: 10.1007/s10519-017-9841-7. Epub 2017 Apr 17.

A New Look at Genetic and Environmental Architecture on Lipids Using Non-Normal Structural Equation Modeling in Male Twins: The NHLBI Twin Study.

Author information

1
Department of Epidemiology & Biostatistics-Laredo Campus, The University of Texas Health at San Antonio, Laredo, TX, USA.
2
Graduate School of Business Sciences, University of Tsukuba, Tokyo, Japan.
3
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
4
Center for Health Sciences, SRI International, Menlo Park, CA, USA.
5
Department of Public Health, Des Moines University, Des Moines, IA, USA. Jun.Dai@dmu.edu.
6
Division of Epidemiology, Department of Medicine, Institute of Medicine and Public Health, Vanderbilt Center for Translational and Clinical Cardiovascular Research (VTRACC), Vanderbilt University Medical Center, Nashville, TN, USA. Jun.Dai@dmu.edu.

Abstract

This study examined genetic and environmental influences on the lipid concentrations of 1028 male twins using the novel univariate non-normal structural equation modeling (nnSEM) ADCE and ACE models. In the best fitting nnSEM ADCE model that was also better than the nnSEM ACE model, additive genetic factors (A) explained 4%, dominant genetic factors (D) explained 17%, and common (C) and unique (E) environmental factors explained 47% and 33% of the total variance of high-density lipoprotein cholesterol (HDL-C). The percentage of variation explained for other lipids was 0% (A), 30% (D), 34% (C) and 37% (E) for low-density lipoprotein cholesterol (LDL-C); 30, 0, 31 and 39% for total cholesterol; and 0, 31, 12 and 57% for triglycerides. It was concluded that additive and dominant genetic factors simultaneously affected HDL-C concentrations but not other lipids. Common and unique environmental factors influenced concentrations of all lipids.

KEYWORDS:

Environmental effect; Genetic effect; Lipids; Non-normal structural equation modeling; Twin

PMID:
28413857
DOI:
10.1007/s10519-017-9841-7
[Indexed for MEDLINE]

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