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J Ginseng Res. 2017 Apr;41(2):127-133. doi: 10.1016/j.jgr.2016.02.001. Epub 2016 Feb 10.

Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2.

Author information

1
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Korea.
2
Institute of Translational Medicine, Qingdao University, Qingdao, China.
3
Korean Ginseng Corporation, Central Research Institute, Daejeon, Korea.
4
Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
5
Department of Bioinformatics and Life Science, Soongsil University, Seoul, Korea.
6
College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.

Abstract

BACKGROUND:

Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects.

METHODS:

The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-α/interferon-γ-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation.

RESULTS:

G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-α and interleukin-1β. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells.

CONCLUSION:

G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.

KEYWORDS:

Panax ginseng; TANK-binding kinase 1; anti-inflammatory activity; ginsenoside Rc; p38

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