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Stem Cell Res. 2017 Mar;19:12-16. doi: 10.1016/j.scr.2016.12.016. Epub 2016 Dec 13.

Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion.

Author information

1
School of Regenerative Medicine, Manipal University, GKVK post, Bellary Road, Bengaluru 560065, Karnataka, India. Electronic address: shagufta.parveen@manipal.edu.
2
National Centre for Biological Sciences, (TIFR), GKVK Campus, Bellary Road, Bengaluru 560065, Karnataka, India. Electronic address: panic@ncbs.res.in.
3
Stempeutics Research Pvt. Ltd., Whitefield, Bengaluru 560066, Karnataka, India. Electronic address: pawan.gupta@stempeutics.com.

Abstract

A major cause of spontaneous abortions is chromosomal abnormality of foetal cells. We report the generation of an induced pluripotent stem cell line from the fibroblasts isolated from chorionic villi of an early spontaneously aborted foetus with Turner syndrome. The Turner syndrome villus induced pluripotent stem cell line is transgene free, retains the original XO karyotype, expresses pluripotency markers and undergoes trilineage differentiation. This pluripotent stem cell model of Turner syndrome should serve as a tool to study the developmental abnormalities of foetus and placenta that lead to early embryo lethality and profound symptoms like infertility in 45 XO survivors.

KEYWORDS:

45 XO embryos; Chromosomal abnormality; Early embryo lethality; Pluripotent stem cell model of Turner syndrome

PMID:
28412999
DOI:
10.1016/j.scr.2016.12.016
[Indexed for MEDLINE]
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