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Pak J Pharm Sci. 2016 Nov;29(6 Spec):2199-2205.

Study on effect of Combivent combined with glucocorticoids in the treatment of patients with AECOPD.

Author information

1
Blood Transfusion Department, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.
2
Clinical laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.
3
Department of Oncology, Yantai City Hospital for Infectious Diseases, Yantai, Shandong, China.
4
Central Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Abstract

We observed the effect of Combivent combined with glucocorticoids in the treatment of patients with AECOPD to explore a better drug treatment for AECOPD. The clinical observation of two clinical curative effective was carried out. Firstly, 100 patients were equally divided into treatment group and control group, who were given basic treatment. The control group was treated with inhalation of salbutamol sulfate and the other was with inhalation of Combivent and glucocorticoid. The clinical effect, dyspnea score, PaO2, PaCO2 and pulmonary function index were observed and compared. The second, 100 patients with AECOPD were divided into the conventional group, the short range group and the long range group, all of that were treated with inhalation of Combivent. The short and the long were treated with glucocorticoid for 7d and 15d.Pulmonary function index was monitored at sixth and fifteenth days after treatment. The incidence of AECOPD was compared with the incidence of complication. Firstly, after 10 days of treatment, the treatment group's total efficiency, dyspnea score, PaO2, PaCO2, were significantly better than the control group and the treatment in the two groups after the above indexes were significant better than those before treatment. The differences were statistically significant (P<0.05). The second time, the short and the long's VC, FVC, FEV1 were higher than the conventional, the recurrence rate was decreased, the incidence of complications in the short was significantly lower than that in the long and the difference was statistically significant (P<0.05). The effect of Combivent combined with glucocorticoid was exactly and the short's complication was low, which is worth to be popularized.

PMID:
28412680

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