Format

Send to

Choose Destination
Cardiol Clin. 2017 May;35(2):185-196. doi: 10.1016/j.ccl.2016.12.001.

Genomic Approaches to Hypertension.

Author information

1
Department of Internal Medicine, Meharry Medical College, 1005 Dr DB Todd Jr Boulevard, Nashville, TN 37208, USA.
2
Cardiovascular Center, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Division of Cardiology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Electronic address: ibenjamin@mcw.edu.

Abstract

Genomic insights and analyses of Mendelian hypertension (HTN) syndromes and Genome-Wide Association study (GWAS) on essential hypertension have contributed to the depth of understanding of the genetics origins of hypertension. Mendelian syndromes are important for the field, since such knowledge leads to specific insights about disease pathogenesis and the potential for precision medicine. The clinical impact of findings of on essential hypertension is continuously evolving, and the insights accrued will refine efforts to combat the societal impact of hypertension. Comprehensive identification of all genomic variants of hypertension, along with their individual associated mechanisms, is paving the way forward in the era of personalized medicine. The overriding challenge for care providers is to reduce health inequities through improved compliance and, perhaps, new paradigms for implementation science that incorporate genomic medicine.

KEYWORDS:

Blood pressure; Genomic approaches; Hypertension

PMID:
28411893
DOI:
10.1016/j.ccl.2016.12.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center