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Biomed J. 2017 Feb;40(1):23-30. doi: 10.1016/j.bj.2017.01.001. Epub 2017 Mar 23.

Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells.

Author information

1
Inserm U1016, Cnrs UMR8104, Cochin Institute, Paris, France; Comparative Cellbiology of Apicomplexan Parasites, Faculty of Medicine, Paris-Descartes University, Paris, France.
2
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK.
3
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK. Electronic address: Margaret.Harnett@glasgow.ac.uk.
4
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
5
DIMNP, UMR CNRS 5235, University of Montpellier, Montpellier, France.
6
Inserm U1016, Cnrs UMR8104, Cochin Institute, Paris, France; Comparative Cellbiology of Apicomplexan Parasites, Faculty of Medicine, Paris-Descartes University, Paris, France. Electronic address: gordon.langsley@inserm.fr.

Abstract

Apicomplexan parasites are responsible for a number of important human pathologies. Obviously, as Eukaryotes they share a number of cellular features and pathways with their respective host cells. One of them is autophagy, a process involved in the degradation of the cell's own components. These intracellular parasites nonetheless seem to present a number of original features compared to their very evolutionarily distant host cells. In mammals and other metazoans, autophagy has been identified as an important contributor to the defence against microbial pathogens. Thus, host autophagy also likely plays a key role in the control of apicomplexan parasites, although its potential manipulation and subversion by intracellular parasites creates a complex interplay in the regulation of host and parasite autophagy. In this mini-review, we summarise current knowledge on autophagy in both parasites and their host cells, in the context of infection by three Apicomplexa: Plasmodium, Toxoplasma, and Theileria.

KEYWORDS:

Autophagy; Cell signalling; Host cell; Plasmodium; Theileria; Toxoplasma

PMID:
28411879
PMCID:
PMC6138587
DOI:
10.1016/j.bj.2017.01.001
[Indexed for MEDLINE]
Free PMC Article

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