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Autoimmun Rev. 2017 Jun;16(6):587-593. doi: 10.1016/j.autrev.2017.04.004. Epub 2017 Apr 12.

Vitamin D and Sjögren syndrome.

Author information

1
Systemic Autoimmune Diseases Research Unit, General Regional Hospital No. 36, Instituto Mexicano del Seguro Social, Puebla, Mexico; Department of Rheumatology and Immunology, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
2
Systemic Autoimmune Diseases Research Unit, General Regional Hospital No. 36, Instituto Mexicano del Seguro Social, Puebla, Mexico.
3
Department of Inmuno-allergology, Puebla Regional Hospital, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, ISSSTE, Puebla, Mexico.
4
Department of Experimental Medicine, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
5
Department of Rheumatology, Centro Medico Nacional La Raza, Instituto Mexicano del Seguro Social, Puebla, Mexico.
6
Laboratorios Clinicos de Puebla, Puebla, Mexico; Universidad de las Américas Puebla, Puebla, Mexico.
7
Department of Rheumatology, Marina Baixa Hospital, Villajoyosa, Alicante, Spain.
8
Department of Dermatology, Indisa Clinic, Santiago de Chile, Chile.
9
Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain. Electronic address: rcervera@clinic.ub.es.

Abstract

The immunomodulatory effects of vitamin D have been extensively studied in the context of autoimmunity. Multiple studies have demonstrated a high prevalence of vitamin D deficiency in autoimmune diseases. Recently, a possible protective role of vitamin D in autoimmunity has been described; however, this function remains controversial. Few studies have investigated the role of vitamin D in patients with Sjögren syndrome (SS). In this review, we compiled the main features of SS pathogenesis, the vitamin D immunomodulatory effects and the possible interaction between both. Data suggests that vitamin D may play a role in the SS pathogenesis. In addition, vitamin D low levels have been found in SS patients, which are associated with extra-glandular manifestations, such as lymphoma or neuropathy, suggesting a possible benefit effect of vitamin D in SS.

KEYWORDS:

Environment; Immunomodulation; Sjögren syndrome; Vitamin D

PMID:
28411165
DOI:
10.1016/j.autrev.2017.04.004
[Indexed for MEDLINE]

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