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Lancet Haematol. 2017 May;4(5):e202-e217. doi: 10.1016/S2352-3026(17)30052-2. Epub 2017 Apr 11.

Worldwide comparison of survival from childhood leukaemia for 1995-2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries.

Collaborators (495)

Bouzbid S, Hamdi-Chérif M, Zaidi Z, Bah E, Swaminathan R, Nortje SH, El Mistiri MM, Bayo S, Malle B, Manraj SS, Sewpaul-Sungkur R, Fabowale, Ogunbiyi OJ, Bradshaw D, Somdyala N, Stefan DC, Abdel-Rahman M, Jaidane L, Mokni M, Kumcher I, Moreno F, González MS, Laura EA, Espinola SB, Calabrano GH, Carballo Quintero B, Fita R, Garcilazo DA, Giacciani PL, Diumenjo MC, Laspada WD, Green MA, Lanza MF, Ibañez SG, Lima CA, de Oliveira EL, Daniel C, Scandiuzzi C, De Souza P, Melo CD, Del Pino K, Laporte C, Curado MP, de Oliveira JC, Veneziano C, Veneziano DB, Azevedo E Silva G, Galaz JC, Moya JA, Herrmann DA, Vargas S, Herrera VM, Uribe CJ, Bravo LE, Arias-Ortiz NE, Jurado DM, Yépez MC, Galán YH, Torres P, Martínez-Reyes F, Pérez-Meza ML, Jaramillo L, Quinto R, Cueva P, Yépez JG, Torres-Cintrón CR, Tortolero-Luna G, Alonso R, Barrios E, Nikiforuk C, Shack L, Coldman AJ, Woods RR, Noonan G, Turner D, Kumar E, Zhang B, McCrate FR, Ryan S, Hannah H, Dewar R, MacIntyre M, Lalany A, Ruta M, Marrett L, Nishri DE, McClure C, Vriends KA, Bertrand C, Louchini R, Robb KI, Stuart-Panko H, Demers S, Wright S, George JT, Shen X, Brockhouse JT, O'Brien DK, Ward KC, Almon L, Bates J, Rycroft R, Mueller L, Phillips C, Brown H, Cromartie B, Schwartz AG, Vigneau F, MacKinnon JA, Wohler B, Bayakly AR, Clarke CA, Glaser SL, West D, Green MD, Hernandez BY, Johnson CJ, Jozwik D, Charlton ME, Lynch CF, Huang B, Tucker TC, Deapen D, Liu L, Hsieh MC, Wu XC, Stern K, Gershman ST, Knowlton RC, Alverson J, Copeland GE, Rogers DB, Lemons D, Williamson LL, Hood M, Hosain GM, Rees JR, Pawlish KS, Stroup A, Key C, Wiggins C, Kahn AR, Schymura MJ, Leung G, Rao C, Giljahn L, Warther B, Pate A, Patil M, Schubert SS, Rubertone JJ, Slack SJ, Fulton JP, Rousseau DL, Janes TA, Schwartz SM, Bolick SW, Hurley DM, Richards J, Whiteside MA, Nogueira LM, Herget K, Sweeney C, Martin J, Wang S, Harrelson DG, Cheteri MK, Farley S, Hudson AG, Borchers R, Stephenson L, Espinoza JR, Weir HK, Edwards BK, Wang N, Yang L, Chen JS, Song GH, Gu XP, Zhang P, Ge HM, Zhao DL, Zhang JH, Zhu FD, Tang JG, Shen Y, Wang J, Li QL, Yang XP, Dong J, Li W, Cheng LP, Chen JG, Huang QH, Huang SQ, Guo GP, Wei K, Chen WQ, Zeng H, Demetriou AV, Pavlou P, Mang WK, Ngan KC, Swaminathan R, Kataki AC, Krishnatreya M, Jayalekshmi PA, Sebastian P, Sapkota SD, Verma Y, Nandakumar A, Suzanna E, Keinan-Boker L, Silverman BG, Ito H, Nakagawa H, Hattori M, Kaizaki Y, Sugiyama H, Utada M, Katayama K, Narimatsu H, Kanemura S, Koike T, Miyashiro I, Yoshii M, Oki I, Shibata A, Matsuda T, Nimri O, Ab Manan A, Pathy NB, Chimedsuren O, Tuvshingerel S, Al Khater A, El Mistiri MM, Al-Eid H, Jung KW, Won YJ, Chiang CJ, Lai MS, Suwanrungruang K, Wiangnon S, Daoprasert K, Pongnikorn D, Geater SL, Sriplung H, Eser S, Yakut CI, Hackl M, Mühlböck H, Oberaigner W, Zborovskaya AA, Aleinikova OV, Henau K, Van Eycken L, Dimitrova N, Valerianova Z, Šekerija M, Zvolský M, Engholm G, Storm H, Innos K, Mägi M, Malila N, Seppä K, Jégu J, Velten M, Cornet E, Troussard X, Bouvier AM, Faivre J, Guizard AV, Bouvier V, Launoy G, Arveux P, Maynadié M, Mounier M, Fournier E, Woronoff AS, Daoulas M, Clavel J, Le Guyader-Peyrou S, Monnereau A, Trétarre B, Colonna M, Cowppli-Bony A, Molinié F, Bara S, Degré D, Ganry O, Lapôtre-Ledoux B, Grosclaude P, Estève J, Bray F, Piñeros M, Sassi F, Stabenow R, Eberle A, Erb C, Nennecke A, Kieschke J, Sirri E, Kajueter H, Emrich K, Zeissig SR, Holleczek B, Eisemann N, Katalinic A, Brenner H, Asquez RA, Kumar V, Ólafsdóttir EJ, Tryggvadóttir L, Comber H, Walsh PM, Sundseth H, Devigili E, Mazzoleni G, Giacomin A, Bella F, Castaing M, Sutera A, Gola G, Ferretti S, Serraino D, Zucchetto A, Lillini R, Vercelli M, Busco S, Pannozzo F, Vitarelli S, Ricci P, Pascucci C, Autelitano M, Cirilli C, Federico M, Fusco M, Vitale MF, Usala M, Cusimano R, Mazzucco W, Michiara M, Sgargi P, Maule MM, Sacerdote C, Tumino R, Di Felice E, Vicentini M, Falcini F, Cremone L, Budroni M, Cesaraccio R, Contrino ML, Tisano F, Fanetti AC, Maspero S, Candela G, Scuderi T, Gentilini MA, Piffer S, Rosso S, Sacchetto L, Caldarella A, La Rosa F, Stracci F, Contiero P, Tagliabue G, Dei Tos AP, Zorzi M, Zanetti R, Baili P, Berrino F, Gatta G, Sant M, Capocaccia R, De Angelis R, Liepina E, Maurina A, Smailyte G, Agius D, Calleja N, Siesling S, Visser O, Larønningen S, Møller B, Dyzmann-Sroka A, Trojanowski M, Gózdz S, Mezyk R, Gradalska-Lampart M, Radziszewska AU, Didkowska JA, Wojciechowska U, Blaszczyk J, Kepska K, Bielska-Lasota M, Kwiatkowska K, Forjaz G, Rego RA, Bastos J, Silva MA, Antunes L, Bento MJ, Mayer-da-Silva A, Miranda A, Coza D, Todescu AI, Valkov MY, Adamcik J, Safaei Diba C, Primic-Žakelj M, Žagar T, Stare J, Almar E, Mateos A, Quirós JR, Bidaurrazaga J, Larrañaga N, Díaz García JM, Marcos AI, Marcos-Gragera R, Vilardell Gil ML, Molina E, Sánchez MJ, Sureda PF, Montserrat MR, Chirlaque MD, Navarro C, Ardanaz EE, Moreno-Iribas CC, Fernández-Delgado R, Peris-Bonet R, Galceran J, Khan S, Lambe M, Camey B, Bouchardy C, Usel M, Ess SM, Herrmann C, Bulliard JL, Maspoli-Conconi M, Frick H, Kuehni CE, Schindler M, Bordoni A, Spitale A, Chiolero A, Konzelmann I, Dehler SI, Matthes KL, Rashbass J, Stiller CA, Fitzpatrick D, Gavin A, Bannon F, Black RJ, Brewster DH, Huws DW, White C, Finan P, Allemani C, Bonaventure A, Carreira H, Coleman MP, Di Carlo V, Harewood R, Liu K, Matz M, Montel L, Nikšić M, Rachet B, Sanz N, Spika D, Stephens R, Peake M, Murphy M, Chalker E, Newman L, Baker D, Soeberg MJ, Aitken J, Scott C, Stokes BC, Venn A, Farrugia H, Giles GG, Threlfall T, Currow D, You H, Hendrix J, Lewis C, Latorre MR, Tanaka LF.

Erratum in

Abstract

BACKGROUND:

Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia.

METHODS:

Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for Oncology, third revision. We excluded data from registries from which the data were judged to be less reliable, or included only lymphomas, and data from countries in which data for fewer than ten children were available for analysis. We also excluded records because of a missing date of birth, diagnosis, or last known vital status. We estimated 5-year net survival (ie, the probability of surviving at least 5 years after diagnosis, after controlling for deaths from other causes [background mortality]) for children by calendar period of diagnosis (1995-99, 2000-04, and 2005-09), sex, and age at diagnosis (<1, 1-4, 5-9, and 10-14 years, inclusive) using appropriate life tables. We estimated age-standardised net survival for international comparison of survival trends for precursor-cell acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML).

FINDINGS:

We analysed data from 89 828 children from 198 registries in 53 countries. During 1995-99, 5-year age-standardised net survival for all lymphoid leukaemias combined ranged from 10·6% (95% CI 3·1-18·2) in the Chinese registries to 86·8% (81·6-92·0) in Austria. International differences in 5-year survival for childhood leukaemia were still large as recently as 2005-09, when age-standardised survival for lymphoid leukaemias ranged from 52·4% (95% CI 42·8-61·9) in Cali, Colombia, to 91·6% (89·5-93·6) in the German registries, and for AML ranged from 33·3% (18·9-47·7) in Bulgaria to 78·2% (72·0-84·3) in German registries. Survival from precursor-cell ALL was very close to that of all lymphoid leukaemias combined, with similar variation. In most countries, survival from AML improved more than survival from ALL between 2000-04 and 2005-09. Survival for each type of leukaemia varied markedly with age: survival was highest for children aged 1-4 and 5-9 years, and lowest for infants (younger than 1 year). There was no systematic difference in survival between boys and girls.

INTERPRETATION:

Global inequalities in survival from childhood leukaemia have narrowed with time but remain very wide for both ALL and AML. These results provide useful information for health policy makers on the effectiveness of health-care systems and for cancer policy makers to reduce inequalities in childhood cancer survival.

FUNDING:

Canadian Partnership Against Cancer, Cancer Focus Northern Ireland, Cancer Institute New South Wales, Cancer Research UK, US Centers for Disease Control and Prevention, Swiss Re, Swiss Cancer Research foundation, Swiss Cancer League, and the University of Kentucky.

PMID:
28411119
PMCID:
PMC5418564
DOI:
10.1016/S2352-3026(17)30052-2
[Indexed for MEDLINE]
Free PMC Article

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