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Lancet Oncol. 2017 Jun;18(6):719-731. doi: 10.1016/S1470-2045(17)30186-9. Epub 2017 Apr 11.

International incidence of childhood cancer, 2001-10: a population-based registry study.

Collaborators (222)

Bouzbid S, Hamdi-Cherif M, Hablas A, Chirpaz E, Buziba N, Chesumbai GC, Manraj SS, Reynders D, Wabinga HR, Chokunonga E, Moreno F, Lima CA, Asturian Laporte C, de Oliveira JC, de Aquino JP, Gallagher SV, Uribe CJ, Bravo LE, Yepez Chamorro MC, Torres Alvarado G, Galán Alvarez YH, Martinez Reyes FC, Castillo Calvas JC, Mendoza Alava M, Cueva Ayala P, Hanchard B, Fajardo-Gutiérrez A, Zavala Zegarra DE, Barrios E, Nikiforuk C, Woods R, Turner D, MacIntyre M, Corriveau A, Navaneelan T, Bertrand C, Stuart-Panko H, Wilson RJ, Kosary C, Shen X, Brockhouse J, Yee GA, Mitchell TC, Snipes K, West D, Rao C, Bolick S, Rycroft RK, Mueller L, Zheng Y, Dosch K, Brown H, Vargas A, Levin GM, Bayakly R, Johnson C, Shen T, Ruppert L, Lynch CF, Lai SM, Tucker TC, Wu XC, Schwenn M, Stern K, Gershman S, Copeland G, Bushhouse S, Rogers DB, Jackson Thompson J, Lemons D, Frederick S, Harris JA, Riddle B, Stroup A, Wiggins C, Schymura MJ, Giljahn LK, Sheikh A, Schubert S, Aldinger W, Fulton JP, Whiteside M, Nogueira L, Sweeney C, Johnson A, Martin J, Farley S, Harrelson D, Malicki R, Espinoza JR, Hernandez BY, Abulfateh N, Wang N, Ngan R, Lingegowda KB, Swaminathan R, Koyande SS, Silverman B, Ozasa K, Kanemura S, Soda M, Miyashiro I, Shibata A, Nimri O, Won YJ, Kim CH, Hong NS, Nam HS, Kweon S, Kim WC, Huh JS, Jung KW, Yoo CI, Elbasmy A, Laudico AV, Lumague MR, AlMutlag H, Buasom R, Srisukho S, Tanabodee J, Wiangnon S, Pongnikorn D, Sriplung H, Dirican O, Eser S, Le Hoang M, Hackl M, Zborovskaya A, Dimitrova N, Valerianova Z, Sekerija M, Pavlou P, Dušek M, Mägi M, Clavel J, Lacour B, Guizard AV, Bouvier V, Troussard X, Woronoff AS, Tretarre B, Colonna M, Molinié F, Bara S, Velten M, Marrer E, Ganry O, Grosclaude P, Kaatsch P, Zeissig SR, Holleczek B, Katalinic A, Jakab Z, Birgisson H, Walsh PM, Mangone L, Merletti F, Magoni M, Mangone L, Ferretti S, Serraino D, Spagnoli G, Fusco M, Michiara M, Tumino R, Falcini F, Sensi F, Tisano F, Piffer S, Stracci F, Tagliabue G, Smailyte G, Agius D, Visser O, Ursin G, Didkowska J, Trojanowski M, Wojciechowska U, Forjaz de Lacerda G, Silva MA, Laranja Pontes J, da Costa Miranda A, Kaiserova E, Primic Žakelj M, Peris-Bonet R, Vicente Raneda ML, Almar Marqués E, Quirós Garcia JR, Ramos Monserrat M, Errezola Saizar M, Alemán Herrera A, Díaz García JM, Marcos-Gragera R, Sanchez-Perez MJ, Ardanaz Aicua E, Galceran J, Klint A, Kuehni CE, Bouchardy C, Levi F, Bordoni A, Konzelmann I, Rohrmann S, Stiller CA, Gavin AT, Brewster DH, Phung H, Rushton S, Guthridge S, Aitken J, D'Onise K, Venn A, Farrugian H, Threlfall TJ, Laumond S, Yen Kai Sun L, Hendrix J, Ballantine K, Colombet M, Dolya A, Masuyer E, Steliarova-Foucher E.

Author information

1
Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France. Electronic address: steliarova@iarc.fr.
2
Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.
3
Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
4
Paediatric Cancer Registry, National Cancer Institute, Buenos Aires, Argentina.
5
Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg Children's Hospital, Tygerberg, South Africa.
6
Seoul National University Children's Hospital, Institute of Cancer Research, Seoul, South Korea.
7
National Cancer Registration and Analysis Service, Public Health England, Oxford, UK.

Erratum in

Abstract

BACKGROUND:

Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control.

METHODS:

This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001-10. Incidence rates per million person-years for the 0-14 years and 0-19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0-4 years, 5-9 years, 10-14 years, and 15-19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0-14 years were compared with comparable data obtained in the 1980s.

FINDINGS:

Of 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001-10. 385 509 incident cases in children aged 0-19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0-14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15-19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0-14 years has increased from 124·0 (95% CI 123·3-124·7) to 140·6 (140·1-141·1) per million person-years.

INTERPRETATION:

This unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research.

FUNDING:

International Agency for Research on Cancer and the Union for International Cancer Control.

Comment in

PMID:
28410997
PMCID:
PMC5461370
DOI:
10.1016/S1470-2045(17)30186-9
[Indexed for MEDLINE]
Free PMC Article

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