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Environ Res. 2017 Jul;156:426-433. doi: 10.1016/j.envres.2017.03.056. Epub 2017 Apr 12.

Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort.

Author information

1
Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address: sffarzan@usc.edu.
2
Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA and Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
3
Department of Population Health, New York University School of Medicine, New York, NY, USA.
4
Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.

Abstract

INTRODUCTION:

Accumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between prenatal As exposure and plasma biomarkers of inflammation and endothelial function in mothers and newborns are lacking.

METHODS:

We examined maternal urinary As levels at gestational weeks 24-28 and levels of inflammatory biomarkers in plasma from 563 pregnant women and 500 infants' cord blood. We assessed a multiplexed panel of circulating inflammatory and endothelial function markers, including tumor necrosis factor alpha (TNFα), monocyte chemoattractant protein 1 (MCP1), intercellular adhesion molecule (ICAM1) and vascular cell adhesion molecule (VCAM1).

RESULTS:

Compared with the bottom tertile, the highest tertile of maternal urinary As during pregnancy was associated with a 145.2ng/ml (95% CI 4.1, 286.3; p=0.04) increase in cord blood ICAM1 and 557.3ng/ml (95% CI -56.4, 1171.1; p=0.09) increase in cord blood VCAM1. Among mothers, the highest tertile of maternal urinary As during pregnancy was related to a 141.8ng/ml (95% CI 26.1, 257.5; p=0.02) increase maternal plasma VCAM1 levels. Urinary As was unrelated to MCP1 or TNFα in maternal plasma and cord blood. In structural equation models, the association between maternal urinary As and infant VCAM was mediated by maternal levels of VCAM (βmediation: 0.024, 95% CI: 0.002, 0.050).

CONCLUSION:

Our observations indicate that As exposure during pregnancy may affect markers of vascular health and endothelial function in both pregnant women and children, and suggest further investigation of the potential impacts on cardiovascular health in these susceptible populations.

KEYWORDS:

Arsenic; Endothelial; Inflammatory markers; New Hampshire; Pregnancy cohort

PMID:
28410520
PMCID:
PMC5477637
DOI:
10.1016/j.envres.2017.03.056
[Indexed for MEDLINE]
Free PMC Article

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